
Acne may heal, but deeper inflammation can sometimes leave permanent indentations behind. These depressed acne scars can make the skin look uneven even after active breakouts have stopped.
Rejuran® S is a targeted polynucleotide (PN) injectable developed specifically for localised depressed scars. Its thicker formulation allows the product to be placed directly into selected scarred areas rather than being distributed across the entire
Rejuran® S is a specialised injectable within the Rejuran® range developed for targeted scar treatment.
It contains polynucleotides (PN), which are DNA fragments derived from salmon-family sources.
The main difference between Rejuran® S and other Rejuran® formulations is its higher viscosity.
Its thicker consistency makes it suitable for precise placement into localised areas such as depressed acne scars instead of being injected broadly across the skin for general skin rejuvenation.
Rejuran® S is therefore primarily used as a scar-focused treatment, rather than a conventional full-face skin booster.

Not every pimple will leave an indentation.
Depressed acne scars usually develop after deeper acne inflammation damages the surrounding skin structure. As the acne heals, the body attempts to rebuild the damaged area by producing new collagen and tissue.
When insufficient tissue is produced during this healing process, the repaired area remains below the level of the surrounding skin.
This creates an atrophic or depressed acne scar.

Rejuran® S is injected directly into selected scarred areas instead of being spread evenly throughout the entire face. Its treatment mechanism can be understood in three stages:

01.
The higher-viscosity formulation allows the doctor to place Rejuran® S precisely into the area beneath or around a depressed scar.
This allows individual scars to be treated according to their location and depth.
02.
After injection, the polynucleotides support the biological environment involved in skin recovery and tissue repair.
This process takes place gradually rather than producing an immediate resurfacing effect.
03.
As the treated tissue undergoes repair, collagen remodelling takes place within the scarred area.
Over time, this may help improve the underlying skin structure and make selected depressed scars appear less noticeable.

Rejuran® S may provide several improvements for acne-scarred skin.
✅ Makes Depressed Scars Appear Shallower
Supports tissue remodelling to make selected indentations appear less noticeable.
✅ Smoothens Uneven Skin Texture
Helps shallow scarred areas appear smoother and more even.
✅ Improves Scarred Skin Appearance
Supports skin recovery for a healthier, more refined appearance.
✅ Provides Focused Scar Treatment
Can be injected directly into individual scars that need more attention.
✅ Gradual Improvement
Results develop progressively through the skin-remodelling process.
Different acne scars have different structures and depths. For this reason, not every scar should be treated in exactly the same way.

Rolling scars are broad depressions with sloping edges.
They create a wavy or uneven appearance across the skin and may sometimes be attached to deeper fibrous tissue.
Rejuran® S may be considered for selected rolling scars, depending on whether significant underlying tethering is present.

Boxcar scars are round or oval depressions with more clearly defined edges.
Shallow to moderate boxcar scars may be considered for targeted Rejuran® S treatment, while deeper scars may require combination treatment.

Ice pick scars are narrow indentations that extend more deeply into the skin.
Because of their depth and structure, deeper ice pick scars may respond better to other scar-specific procedures or combination treatments rather than Rejuran® S alone.

Many individuals have more than one type of acne scar.
For example, the cheeks may contain a combination of rolling, boxcar and ice pick scars.
In these cases, your doctor may recommend different treatments for different scars rather than using one procedure across the entire area.

Rejuran® S may be considered for individuals with:
Suitability is determined more by the structure and depth of the scar than simply how visible the scar appears.

Temporary injection marks are expected because Rejuran® S is administered directly into the skin. Immediately after treatment, you may notice:
These generally settle gradually over the following few days.
Improvement in acne scars is not immediate. Changes develop progressively as the treated skin undergoes tissue repair and remodelling.
Both treatments belong to the Rejuran® family and contain polynucleotides, but they serve different purposes.
| Rejuran® S | Rejuran® Healer | |
|---|---|---|
| Main Purpose | Depressed acne scars | Overall skin rejuvenation |
| Consistency | Higher viscosity | Lower viscosity |
| Treatment Method | Targeted into individual scar areas | Distributed across larger skin areas |
| Main Concern | Scar indentations and uneven scar texture | General skin quality and elasticity |
| Treatment Coverage | Localised | Broader areas of the face |
The choice should therefore depend on the skin concern rather than assuming one formulation is simply “stronger” than the other.
If acne scars are the main concern, Rejuran® S may be considered.
If the objective is more general skin rejuvenation, another Rejuran® formulation may be more appropriate.
Rejuran® S is primarily an acne scar treatment, not a treatment for active breakouts.
If significant active acne is still present, controlling the inflammation first may be recommended.
Continuing breakouts can cause additional skin damage and create new scars even while existing scars are being treated.
Your doctor may therefore recommend an active acne treatment before or alongside an acne scar treatment plan.


Rejuran® S involves multiple targeted injections, so some discomfort may occur.
Numbing cream is usually applied before the treatment to improve comfort.
During injection, patients may experience:
The level of discomfort differs between individuals and may also depend on the number and location of scars being treated.
| Overview of Rejuran® S | |
|---|---|
| Treatment Time | 30 – 45 Minutes |
| Recommended Sessions | 3 – 4 Sessions |
| Recommended Intervals | Every 3-4 Weeks |
| Downtime | 1 – 3 days of small injection marks |
| Treatment Price | RM1,800 NETT |
We gathered the answers to some popular questions below. If you can’t find your question below feel free to contact us, and we’ll be happy to help.
Rejuran S may be suitable for individuals with depressed acne scars, including boxcar and rolling scars. For deeper or more severe scarring, it may be combined with treatments such as Fractional CO2 Laser or Pico Laser. A doctor will assess your skin and recommend a suitable treatment plan.
Rejuran S is injected directly into targeted scar areas using a fine needle. Mild stinging or discomfort may be experienced, and numbing cream can be applied before treatment for greater comfort.
Most patients may require around 3–4 sessions, usually spaced about 4 weeks apart. The number of sessions depends on the type and severity of the acne scars.
Mild redness, swelling, bruising or small injection marks may occur and usually improve within 1–3 days. If Rejuran S is combined with subcision or laser treatment, the downtime may be longer depending on the procedure.
Skin improvement may gradually become noticeable within the first month as collagen remodelling takes place. Results and longevity vary depending on the individual’s skin condition, scar severity and treatment plan.
After treatment, avoid excessive sun exposure, saunas, strenuous exercise and alcohol for a short period. Strong active skincare ingredients such as AHA, BHA and retinol should also be avoided until the skin has settled. Use gentle skincare and apply sunscreen regularly.